Structure of PDB 1gpl Chain A Binding Site BS01

Receptor Information

>1gpl Chain A (length=432) Species: 9606,10141

AEVCYSHLGCFSDEKPWAGTSQRPIKSLPSDPKKINTRFLLYTNENQNSY
QLITATDIATIKASNFNLNRKTRFIIHGFTDSGENSWLSDMCKNMFQVEK
VNCICVDWKGGSKAQYSQASQNIRVVGAEVAYLVQVLSTSLNYAPENVHI
IGHSLGAHTAGEAGKRLNGLVGRITGLDPAEPYFQDTPEEVRLDPSDAKF
VDVIHTDISPILPSLGFGMSQKVGHMDFFPNGGKDMPGCKTGISCNHHRS
IEYYHSSILNPEGFLGYPCASYDEFQESGCFPCPAKGCPKMGHFADQYPG
KTNAVEQTFFLNTGASDNFTRWRYKVSVTLSGKKVTGHILVSLFGNKGNS
KQYEIFKGTLKPDSTHSNEFDSDVDVGDLQMVKFIWYNNVINPTLPRVGA
SKIIVETNVGKQFNFCSPETVREEVLLTLTPC

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 1gpl Chain A Residue 500

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1gpl A pancreatic lipase with a phospholipase A1 activity: crystal structure of a chimeric pancreatic lipase-related protein 2 from guinea pig.
• Resolution: 2.01 Å
• Binding residue (original residue number in PDB): E187 R190 D192 D195
• Binding residue (residue number reindexed from 1): E189 R192 D194 D197
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): F77 S152 L153 D176 H263
• Catalytic site (residue number reindexed from 1): F79 S154 L155 D178 H247
• Enzyme Commision number: 3.1.1.26: galactolipase.
  3.1.1.3: triacylglycerol lipase.

Gene Ontology

Molecular Function

• GO:0004806 triacylglycerol lipase activity
• GO:0016298 lipase activity
• GO:0052689 carboxylic ester hydrolase activity

Biological Process

• GO:0006629 lipid metabolic process

External links

• PDB: RCSB:1gpl, PDBe:1gpl, PDBj:1gpl
• PDBsum: 1gpl
• PubMed: 8939760
• UniProt: P16233|LIPP_HUMAN Pancreatic triacylglycerol lipase (Gene Name=PNLIP);
  P81139