Structure of PDB 1gpb Chain A Binding Site BS01

Receptor Information
>1gpb Chain A (length=823) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTVRDHLVGRWI
RTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLD
MEELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQ
KICGGWQMEEADDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDT
QVVLAMPYDTPVPGYRNNVVNTMRLWSAKAPNDFNLKDFNVGGYIQAVLD
RNLAENISRVLYPNDNFFEGKELRLKQEYFVVAATLQDIIRRFKSSKFGC
RDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRVLVDLERLDWDKAWEVT
VKTCAYTNHTVIPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAF
PGDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIF
KDFYELEPHKFQNKTNGITPRRWLVLCNPGLAEIIAERIGEEYISDLDQL
RKLLSYVDDEAFIRDVAKVKQENKLKFAAYLEREYKVHINPNSLFDVQVK
RIHEYKRQLLNCLHVITLYNRIKKEPNKFVVPRTVMIGGKAAPGYHMAKM
IIKLITAIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPAADLSEQIST
AGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDV
DRLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLMHH
DRFKVFADYEEYVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIA
QYAREIWGVEPSRQRLPAPDEKI
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain1gpb Chain A Residue 999 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1gpb Structural Changes in Glycogen Phosphorylase Induced by Phosphorylation
Resolution1.9 Å
Binding residue
(original residue number in PDB)		G134 K568 Y648 R649 V650 G675 T676 G677 K680
Binding residue
(residue number reindexed from 1)		G116 K550 Y630 R631 V632 G657 T658 G659 K662
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H377 K568 R569 K574 T676 K680
Catalytic site (residue number reindexed from 1) H359 K550 R551 K556 T658 K662
Enzyme Commision number 2.4.1.1: glycogen phosphorylase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004645 1,4-alpha-oligoglucan phosphorylase activity
GO:0008184 glycogen phosphorylase activity
GO:0016757 glycosyltransferase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005977 glycogen metabolic process
GO:0005980 glycogen catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0098723 skeletal muscle myofibril

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1gpb, PDBe:1gpb, PDBj:1gpb
PDBsum1gpb
PubMed
UniProtP00489|PYGM_RABIT Glycogen phosphorylase, muscle form (Gene Name=PYGM)

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