Structure of PDB 1gji Chain A Binding Site BS01

Receptor Information

>1gji Chain A (length=275) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PYIEIFEQPRQRGMRFRYKCEGRSAGSIPGEHSTDNNKTFPSIQILNYFG
KVKIRTTLVTKNEPYKPHPHDLVGKDCRDGYYEAEFGPERRVLSFQNLGI
QCVKKKDLKESISLRISKKINPFNVPEEQLHNIDEYDLNVVRLCFQAFLP
DEHGNYTLALPPLISNPIYDNRAPNTAELRICRVNKNCGSVKGGDEIFIL
CDKVQKDDIEVRFVLDNWEAKGSFSQADVHRQVAIVFRTPPFLRDITEPI
TVKMQLRRPSDQEVSEPMDFRYLPD

Ligand information

>1gji Chain C (length=20) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gggtttaaagaaattccaga

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1gji X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2.
Resolution	2.85 Å
Binding residue (original residue number in PDB)	Y24 C26 K110 K111 R178 P180 Q211 K212 Q238
Binding residue (residue number reindexed from 1)	Y18 C20 K104 K105 R172 P174 Q205 K206 Q232
Binding affinity	PDBbind-CN: Kd=25nM

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005737	cytoplasm

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Cellular Component

External links

PDB	RCSB:1gji, PDBe:1gji, PDBj:1gji
PDBsum	1gji
PubMed	11587641
UniProt	P16236\|REL_CHICK Proto-oncogene c-Rel (Gene Name=REL)

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