Structure of PDB 1g86 Chain A Binding Site BS01

Receptor Information
>1g86 Chain A (length=141) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLLPVPYTEAASLSTGSTVTIKGRPLVCFLNEPYLQVDFHTEMKEESDIV
FHFQVCFGRRVVMNSREYGAWKQQVESKNMPFQDGQEFELSISVLPDKYQ
VMVNGQSSYTFDHRIKPEAVKMVQVWRDISLTKFNVSYLKR
Ligand information
Ligand IDNEQ
InChIInChI=1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3
InChIKeyHDFGOPSGAURCEO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341
OpenEye OEToolkits 1.5.0		CCN1C(=O)C=CC1=O
ACDLabs 10.04O=C1C=CC(=O)N1CC
FormulaC6 H7 N O2
NameN-ETHYLMALEIMIDE
ChEMBLCHEMBL8211
DrugBankDB02967
ZINCZINC000000901367
PDB chain1g86 Chain A Residue 143 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1g86 Charcot-Leyden crystal protein (galectin-10) is not a dual function galectin with lysophospholipase activity but binds a lysophospholipase inhibitor in a novel structural fashion.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		C29 D85
Binding residue
(residue number reindexed from 1)		C28 D84
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.1.5: lysophospholipase.
Gene Ontology
Molecular Function
GO:0004622 lysophospholipase activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
GO:0042802 identical protein binding
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
Biological Process
GO:0002667 regulation of T cell anergy
GO:0002724 regulation of T cell cytokine production
GO:0046006 regulation of activated T cell proliferation
GO:0070231 T cell apoptotic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0062023 collagen-containing extracellular matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1g86, PDBe:1g86, PDBj:1g86
PDBsum1g86
PubMed11834744
UniProtQ05315|LEG10_HUMAN Galectin-10 (Gene Name=CLC)

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