Structure of PDB 1g0d Chain A Binding Site BS01

Receptor Information
>1g0d Chain A (length=666) Species: 143350 (Pagrus major) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLIVDVNGRSHENNLAHRTREIDRERLIVRRGQPFSITLQCSDSLPPKHH
LELVLHLGKRDEVVIKVQKEHGARDKWWFNQQGAQDEILLTLHSPANAVI
GHYRLAVLVMSPDGHIVERADKISFHMLFNPWCRDDMVYLPDESKLQEYV
MNEDGVIYMGTWDYIRSIPWNYGQFEDYVMDICFEVLDNSPAALKNSEMD
IEHRSDPVYVGRTITAMVNSNGDRGVLTGRWEEPYTDGVAPYRWTGSVPI
LQQWSKAGVRPVKYGQCWVFAAVACTVLRCLGIPTRPITNFASAHDVDGN
LSVDFLLNERLESLDSRQRSDSSWNFHCWVESWMSREDLPEGNDGWQVLD
PTPQELSDGEFCCGPCPVAAIKEGNLGVKYDAPFVFAEVNADTIYWIVQK
DGQRRKITEDHASVGKNISTKSVYGNHREDVTLHYKYPEGSQKEREVYKK
AGRRVTRLQLSIKHAQPVFGTDFDVIVEVKNEGGRDAHAQLTMLAMAVTY
NSLRRGECQRKTISVTVPAHKAHKEVMRLHYDDYVRCVSEHHLIRVKALL
DAPGPIMTVANIPLSTPELLVQVPGKAVVWEPLTAYVSFTNPLPVPLKGG
VFTLEGAGLLSATQIHVNGAVAPSGKVSVKLSFSPMRTGVRKLLVDFDSD
RLKDVKGVTTVVVHKK
Ligand information
Ligand IDSO4
InChIInChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
InChIKeyQAOWNCQODCNURD-UHFFFAOYSA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[O-]S(=O)(=O)[O-]
CACTVS 3.341[O-][S]([O-])(=O)=O
ACDLabs 10.04[O-]S([O-])(=O)=O
FormulaO4 S
NameSULFATE ION
ChEMBL
DrugBankDB14546
ZINC
PDB chain1g0d Chain A Residue 696 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1g0d Crystal structure of red sea bream transglutaminase.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		K150 R291 W351 H439
Binding residue
(residue number reindexed from 1)		K145 R286 W346 H434
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) W236 C272 H332 D355 Y515
Catalytic site (residue number reindexed from 1) W231 C267 H327 D350 Y500
Enzyme Commision number 2.3.1.-
2.3.2.13: protein-glutamine gamma-glutamyltransferase.
3.4.-.-
3.5.1.44: protein-glutamine glutaminase.
Gene Ontology
Molecular Function
GO:0003810 protein-glutamine gamma-glutamyltransferase activity
GO:0005509 calcium ion binding
GO:0005525 GTP binding
GO:0008233 peptidase activity
GO:0016746 acyltransferase activity
GO:0046872 metal ion binding
GO:0050568 protein-glutamine glutaminase activity
GO:0120294 peptide serotonyltransferase activity
GO:0120295 histone serotonyltransferase activity
GO:0120296 peptide dopaminyltransferase activity
GO:0120297 histone dopaminyltransferase activity
GO:0120298 peptide noradrenalinyltransferase activity
GO:0120299 peptide histaminyltransferase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0006508 proteolysis
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007399 nervous system development
GO:0018149 peptide cross-linking
GO:0018277 protein deamination
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0051057 positive regulation of small GTPase mediated signal transduction
GO:0051260 protein homooligomerization
GO:0060348 bone development
GO:1903351 cellular response to dopamine
GO:1904015 cellular response to serotonin
GO:2000425 regulation of apoptotic cell clearance
Cellular Component
GO:0000785 chromatin
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0062023 collagen-containing extracellular matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1g0d, PDBe:1g0d, PDBj:1g0d
PDBsum1g0d
PubMed11080504
UniProtP52181|TGM2_PAGMA Protein-glutamine gamma-glutamyltransferase 2 (Gene Name=tgm2)

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