Structure of PDB 1fxu Chain A Binding Site BS01
Receptor Information
>1fxu Chain A (length=278) Species:
9913
(Bos taurus) [
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GYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEI
PNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVF
RLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGQNPLRGPNEE
RFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETV
AECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDTGKAN
HEEVLEAGKQAAQKLEQFVSLLMASIPV
Ligand information
Ligand ID
PO4
InChI
InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKey
NBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
Software
SMILES
CACTVS 3.341
[O-][P]([O-])([O-])=O
ACDLabs 10.04
[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0
[O-]P(=O)([O-])[O-]
Formula
O4 P
Name
PHOSPHATE ION
ChEMBL
DrugBank
DB14523
ZINC
PDB chain
1fxu Chain A Residue 291 [
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Receptor-Ligand Complex Structure
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PDB
1fxu
Calf spleen purine nucleoside phosphorylase: structure of its ternary complex with an N(7)-acycloguanosine inhibitor and a phosphate anion.
Resolution
2.2 Å
Binding residue
(original residue number in PDB)
G32 S33 R84 H86 N115 S220
Binding residue
(residue number reindexed from 1)
G29 S30 R81 H83 N112 S217
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
S33 H64 H86 Y88 E89 A116 M219 S220 N243 V245 H257
Catalytic site (residue number reindexed from 1)
S30 H61 H83 Y85 E86 A113 M216 S217 N240 V242 H251
Enzyme Commision number
2.4.2.1
: purine-nucleoside phosphorylase.
Gene Ontology
Molecular Function
GO:0003824
catalytic activity
GO:0004731
purine-nucleoside phosphorylase activity
GO:0016757
glycosyltransferase activity
GO:0016763
pentosyltransferase activity
GO:0047975
guanosine phosphorylase activity
Biological Process
GO:0006139
nucleobase-containing compound metabolic process
GO:0006166
purine ribonucleoside salvage
GO:0009116
nucleoside metabolic process
Cellular Component
GO:0005737
cytoplasm
View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:1fxu
,
PDBe:1fxu
,
PDBj:1fxu
PDBsum
1fxu
PubMed
11134924
UniProt
P55859
|PNPH_BOVIN Purine nucleoside phosphorylase (Gene Name=PNP)
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