Structure of PDB 1fw6 Chain A Binding Site BS01

Receptor Information
>1fw6 Chain A (length=759) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERL
ARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEP
AEEAEGLVRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDV
STGEFKGTVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPV
MLSEAPFEPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFM
RLPEATLRALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRG
PLEARLDRVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLG
ALRRSLQILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLI
REGYDPDLDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYL
EVTRPYYERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREE
EVFLEVRERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDR
LQIRAGRHPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIA
LLAQVGSFVPAEEAHLPLFDGIYTRIGAGKSTFMVEMEEVALILKEATEN
SLVLLDEVGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLP
RLKNLHVAAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARAR
ALLQAMAAR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1fw6 Composite active site of an ABC ATPase: MutS uses ATP to verify mismatch recognition and authorize DNA repair.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		F39 E41 V57 T59 M70 G72 L470 K471 R473 R475
Binding residue
(residue number reindexed from 1)		F39 E41 V57 T59 M70 G72 L470 K471 R473 R475
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0005524 ATP binding
GO:0030983 mismatched DNA binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0006281 DNA repair
GO:0006298 mismatch repair

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Molecular Function
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Biological Process
External links
PDB RCSB:1fw6, PDBe:1fw6, PDBj:1fw6
PDBsum1fw6
PubMed11172706
UniProtQ56215|MUTS_THEAQ DNA mismatch repair protein MutS (Gene Name=mutS)

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