Structure of PDB 1fut Chain A Binding Site BS01

Receptor Information
>1fut Chain A (length=106) Species: 5127 (Fusarium fujikuroi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QSATTCGSTNYSASQVRAAANAACQYYQNDDTAGSSTYPHTYNNYEGFDF
PVDGPYQEFPIKSGGVYTGGSPGADRVVINTNCEYAGAITHTGASGNNFV
GCSGTN
Ligand information
Ligand ID2GP
InChIInChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(23-24(19,20)21)5(17)3(1-16)22-9/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyWTIFIAZWCCBCGE-UUOKFMHZSA-N
SMILES
SoftwareSMILES
CACTVS 3.341NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO)[CH](O)[CH]3O[P](O)(O)=O
CACTVS 3.341NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O[P](O)(O)=O
OpenEye OEToolkits 1.5.0c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)OP(=O)(O)O)N=C(NC2=O)N
OpenEye OEToolkits 1.5.0c1nc2c(n1C3C(C(C(O3)CO)O)OP(=O)(O)O)N=C(NC2=O)N
ACDLabs 10.04O=C1c2ncn(c2N=C(N)N1)C3OC(C(O)C3OP(=O)(O)O)CO
FormulaC10 H14 N5 O8 P
NameGUANOSINE-2'-MONOPHOSPHATE
ChEMBL
DrugBankDB01937
ZINCZINC000005224737
PDB chain1fut Chain A Residue 108 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1fut Crystal structures of ribonuclease F1 of Fusarium moniliforme in its free form and in complex with 2'GMP.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		Y38 H40 Y42 N43 N44 Y45 E46 E58 N98 F100
Binding residue
(residue number reindexed from 1)		Y38 H40 Y42 N43 N44 Y45 E46 E58 N97 F99
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) Y38 H40 E58 R77 H92 F100
Catalytic site (residue number reindexed from 1) Y38 H40 E58 R76 H91 F99
Enzyme Commision number 4.6.1.24: ribonuclease T1.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004521 RNA endonuclease activity
GO:0004540 RNA nuclease activity
GO:0016829 lyase activity
GO:0046589 ribonuclease T1 activity

View graph for
Molecular Function
External links
PDB RCSB:1fut, PDBe:1fut, PDBj:1fut
PDBsum1fut
PubMed8386773
UniProtP10282|RNF1_GIBFU Guanyl-specific ribonuclease F1

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