Structure of PDB 1fui Chain A Binding Site BS01

Receptor Information
>1fui Chain A (length=591) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKKISLPKIGIRPVIDGRRMGVRESLEEQTMNMAKATAALLTEKLRHACG
AAVECVISDTCIAGMAEAAACEEKFSSQNVGLTITVTPCWCYGSETIDMD
PTRPKAIWGFNGTERPGAVYLAAALAAHSQKGIPAFSIYGHDVQDADDTS
IPADVEEKLLRFARAGLAVASMKGKSYLSLGGVSMGIAGSIVDHNFFESW
LGMKVQAVDMTELRRRIDQKIYDEAELEMALAWADKNFRYGEDENNKQYQ
RNAEQSRAVLRESLLMAMCIRDMMQGNSKLADIGRVEESLGYNAIAAGFQ
GQRHWTDQYPNGDTAEAILNSSFDWNGVREPFVVATENDSLNGVAMLMGH
QLTGTAQVFADVRTYWSPEAIERVTGHKLDGLAEHGIIHLINSGSAALDG
SCKQRDSEGNPTMKPHWEISQQEADACLAATEWCPAIHEYFRGGGYSSRF
LTEGGVPFTMTRVNIIKGLGPVLQIAEGWSVELPKDVHDILNKRTNSTWP
TTWFAPRLTGKGPFTDVYSVMANWGANHGVLTIGHVGADFITLASMLRIP
VCMHNVEETKVYRPSAWAAHGMDIEGQDYRACQNYGPLYKR
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain1fui Chain A Residue 592 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1fui Structure and mechanism of L-fucose isomerase from Escherichia coli.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		E337 D361 H528
Binding residue
(residue number reindexed from 1)		E337 D361 H528
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) E337 D361 H528
Catalytic site (residue number reindexed from 1) E337 D361 H528
Enzyme Commision number 5.3.1.25: L-fucose isomerase.
5.3.1.3: D-arabinose isomerase.
Gene Ontology
Molecular Function
GO:0008736 L-fucose isomerase activity
GO:0008790 arabinose isomerase activity
GO:0016853 isomerase activity
GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses
GO:0030145 manganese ion binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0005996 monosaccharide metabolic process
GO:0006004 fucose metabolic process
GO:0019317 fucose catabolic process
GO:0019571 D-arabinose catabolic process
GO:0042355 L-fucose catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1fui, PDBe:1fui, PDBj:1fui
PDBsum1fui
PubMed9367760
UniProtP69922|FUCI_ECOLI L-fucose isomerase (Gene Name=fucI)

[Back to BioLiP]