Structure of PDB 1ftl Chain A Binding Site BS01

Receptor Information
>1ftl Chain A (length=257) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLT
IVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSK
PFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAV
FDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRK
PCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKW
WYDKGEC
Ligand information
Ligand IDDNQ
InChIInChI=1S/C8H2N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H
InChIKeyYEUPBRRGMWBCEB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C1=C(C(=CC2=NC(=O)C(=O)N=C21)[N+](=O)[O-])[N+](=O)[O-]
CACTVS 3.341[O-][N+](=O)C1=CC2=NC(=O)C(=O)N=C2C=C1[N+]([O-])=O
ACDLabs 10.04[O-][N+](=O)C=2C(=CC1=NC(=O)C(=O)N=C1C=2)[N+]([O-])=O
FormulaC8 H2 N4 O6
Name6,7-DINITROQUINOXALINE-2,3-DIONE;
DNQX
ChEMBL
DrugBank
ZINCZINC000003871177
PDB chain1ftl Chain A Residue 365 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1ftl Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		E13 Y61 P89 L90 T91 R96 E193 M196 Y220
Binding residue
(residue number reindexed from 1)		E9 Y57 P85 L86 T87 R92 E189 M192 Y216
Annotation score1
Binding affinityMOAD: ic50=998nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
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Cellular Component
External links
PDB RCSB:1ftl, PDBe:1ftl, PDBj:1ftl
PDBsum1ftl
PubMed11086992
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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