Structure of PDB 1fqk Chain A Binding Site BS01

Receptor Information

>1fqk Chain A (length=318) Species: 9913,10116

RTVKLLLLGAGESGKSTIVKQMKIIHQDGYSLEECLEFIAIIYGNTLQSI
LAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEEGTMPKEMSDIIQRLW
KDSGIQACFDRASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVKT
TGIIETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYD
LVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKS
PLTICYPEYAGSNTYEEAGNYIKVQFLELNMRRDVKEIYSHMTCATDTQN
VKFVFDAVTDIIIKENLK

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 1fqk Chain A Residue 352

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1fqk Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A.
• Resolution: 2.3 Å
• Binding residue (original residue number in PDB): S43 T177
• Binding residue (residue number reindexed from 1): S16 T150
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): E39 T44 R174 D196 Q200
• Catalytic site (residue number reindexed from 1): E12 T17 R147 D169 Q173

Gene Ontology

Molecular Function

• GO:0003924 GTPase activity
• GO:0005525 GTP binding
• GO:0019001 guanyl nucleotide binding
• GO:0031683 G-protein beta/gamma-subunit complex binding

Biological Process

• GO:0007165 signal transduction
• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway

External links

• PDB: RCSB:1fqk, PDBe:1fqk, PDBj:1fqk
• PDBsum: 1fqk
• PubMed: 11234020
• UniProt: P04695|GNAT1_BOVIN Guanine nucleotide-binding protein G(t) subunit alpha-1 (Gene Name=GNAT1);
  P10824|GNAI1_RAT Guanine nucleotide-binding protein G(i) subunit alpha-1 (Gene Name=Gnai1)