Structure of PDB 1fpw Chain A Binding Site BS01

Receptor Information

>1fpw Chain A (length=190) Species: 4932 (Saccharomyces cerevisiae)

MGAKTSKLSKDDLTCLKQSTYFDRREIQQWHKGFLRDCPSGQLAREDFVK
IYKQFFPFGSPEDFANHLFTVFDKDNNGFIHFEEFITVLSTTSRGTLEEK
LSWAFELYDLNHDGYITFDEMLTIVASVYKMMGSMVTLNEDEATPEMRVK
KIFKLMDKNEDGYITLDEFREGSKVDPSIIGALNLYDGLI

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 1fpw Chain A Residue 500

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1fpw Structure and calcium-binding properties of Frq1, a novel calcium sensor in the yeast Saccharomyces cerevisiae.
• Resolution: N/A
• Binding residue (original residue number in PDB): D73 D75 N77 F79 H81 E84
• Binding residue (residue number reindexed from 1): D73 D75 N77 F79 H81 E84
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding
• GO:0005515 protein binding
• GO:0008047 enzyme activator activity
• GO:0046872 metal ion binding

Biological Process

• GO:0009966 regulation of signal transduction

Cellular Component

• GO:0000139 Golgi membrane
• GO:0005829 cytosol
• GO:0005886 plasma membrane
• GO:0016020 membrane
• GO:0033101 cellular bud membrane
• GO:0043231 intracellular membrane-bounded organelle

External links

• PDB: RCSB:1fpw, PDBe:1fpw, PDBj:1fpw
• PDBsum: 1fpw
• PubMed: 11015193
• UniProt: Q06389|NCS1_YEAST Calcium-binding protein NCS-1 (Gene Name=FRQ1)