Structure of PDB 1fmw Chain A Binding Site BS01

Receptor Information
>1fmw Chain A (length=738) Species: 44689 (Dictyostelium discoideum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NPIHDRTSDYHKYLKVKQGDSDLFKLTVSDKRYIWYNPDPKERDSYECGE
IVSETSDSFTFKTVDGQDRQVKKDDANQRNPIKFDGVEDMSELSYLNEPA
VFHNLRVRYNQDLIYTYSGLFLVAVNPFKRIPIYTQEMVDIFKGRRRNEV
APHIFAISDVAYRSMLDDRQNQSLLITGESGAGKTENTKKVIQYLASVAG
RGVLEQQILQANPILEAFGNAKTTRNNNSSRFGKFIEIQFNNAGFISGAS
IQSYLLEKSRVVFQSETERNYHIFYQLLAGATAEEKKALHLAGPESFNYL
NQSGCVDIKGVSDSEEFKITRQAMDIVGFSQEEQMSIFKIIAGILHLGNI
KFEKGAGEGAVLKDKTALNAASTVFGVNPSVLEKALMEPRILAGRDLVAQ
HLNVEKSSSSRDALVKALYGRLFLWLVKKINNVLCQERKAYFIGVLDISG
FEIFKVNSFEQLCINYTNEKLQQFFNHHMFKVEQEEYLKEKIDSQATIDL
IDGRQPPGILALLDEQSVFPNATDNTLITKLHSHFSKKNAKYEEPRFSKT
EFGVTHYAGQVMYEIQDWLEKNKDPLQQDLELCFKDSSDNVVTKLFNDPN
IASRAFITVAAQYKEQLASLMATLETTNPHFVRCIIPNNKQLPAKLEDKV
VLDQLRCNGVLEGIRITRKGFPNRIIYADFVKRYYLLAPNVPRDAEDSQK
ATDAVLKHLNIDPEQYRFGITKIFFRAGQLARIEEARE
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain1fmw Chain A Residue 800 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1fmw X-ray structures of the apo and MgATP-bound states of Dictyostelium discoideum myosin motor domain.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		T186 S237
Binding residue
(residue number reindexed from 1)		T185 S230
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) S181 G182 T186 N233 S236 S237 G457 E459
Catalytic site (residue number reindexed from 1) S180 G181 T185 N226 S229 S230 G450 E452
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
GO:0051015 actin filament binding
Cellular Component
GO:0016459 myosin complex

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:1fmw, PDBe:1fmw, PDBj:1fmw
PDBsum1fmw
PubMed10954715
UniProtP08799|MYS2_DICDI Myosin-2 heavy chain (Gene Name=mhcA)

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