Structure of PDB 1fm6 Chain A Binding Site BS01
Receptor Information
>1fm6 Chain A (length=232) Species:
9606
(Homo sapiens) [
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NEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQL
FTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILL
ATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLF
NPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALR
SIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAP
Ligand information
>1fm6 Chain B (length=10) Species:
9606
(Homo sapiens) [
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HKILHRLLQE
Receptor-Ligand Complex Structure
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PDB
1fm6
Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors.
Resolution
2.1 Å
Binding residue
(original residue number in PDB)
V280 K284 L294 V298 R302 F450 E453
Binding residue
(residue number reindexed from 1)
V54 K58 L68 V72 R76 F224 E227
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0003677
DNA binding
GO:0003707
nuclear steroid receptor activity
GO:0008270
zinc ion binding
Biological Process
GO:0006355
regulation of DNA-templated transcription
Cellular Component
GO:0005634
nucleus
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Molecular Function
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Cellular Component
External links
PDB
RCSB:1fm6
,
PDBe:1fm6
,
PDBj:1fm6
PDBsum
1fm6
PubMed
10882139
UniProt
P19793
|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)
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