Structure of PDB 1fm1 Chain A Binding Site BS01

Receptor Information

>1fm1 Chain A (length=158) Species: 9606 (Homo sapiens)

TLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDG
IADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTS
SSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDV
QGIQSLYG

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 1fm1 Chain A Residue 166

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1fm1 High-resolution solution structure of the catalytic fragment of human collagenase-3 (MMP-13) complexed with a hydroxamic acid inhibitor.
• Resolution: N/A
• Binding residue (original residue number in PDB): H119 H123 H129
• Binding residue (residue number reindexed from 1): H113 H117 H123
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): H119 E120 H123 H129
• Catalytic site (residue number reindexed from 1): H113 E114 H117 H123
• Enzyme Commision number: 3.4.24.-

Gene Ontology

Molecular Function

• GO:0004222 metalloendopeptidase activity
• GO:0008237 metallopeptidase activity
• GO:0008270 zinc ion binding

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0031012 extracellular matrix

External links

• PDB: RCSB:1fm1, PDBe:1fm1, PDBj:1fm1
• PDBsum: 1fm1
• PubMed: 10986126
• UniProt: P45452|MMP13_HUMAN Collagenase 3 (Gene Name=MMP13)