Structure of PDB 1fgs Chain A Binding Site BS01

Receptor Information

>1fgs Chain A (length=393) Species: 1582 (Lacticaseibacillus casei)

MNYTETVAYIHSFPRLAGDHRRILTLLHALGNPQQQGRYIHVTGTNGKGS
AANAIAHVLEASGLTVGLYTSPFIMRFNERIMIDHEPIPDAALVNAVAFV
RAALERLQQQQADFNVTEFEFITALAYWYFRQRQVDVAVIEVGDSTNVIT
PVVSVLTEVALDTITAIAKHKAGIIKRGIPVVTGNLVPDAAAVVAAKVAT
TGSQWLRFDRDFSVPKAKLHGWGQRFTYEDQDGRISDLEVPLVGDYQQRN
MAIAIQTAKVYAKQTEWPLTPQNIRQGLAASHWPARLEKISDTPLIVIDG
AHNPDGINGLITALKQLFSQPITVIAGYAAMADRLTAAFSTVYLVPVPGT
PRGRLKDSWQEALAASLNDVPDQPIVITGSLYLASAVRQTLLG

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 1fgs Chain A Residue 998

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1fgs Structural homologies with ATP- and folate-binding enzymes in the crystal structure of folylpolyglutamate synthetase.
• Resolution: 2.4 Å
• Binding residue (original residue number in PDB): S73 E143
• Binding residue (residue number reindexed from 1): S71 E141
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 6.3.2.17: tetrahydrofolate synthase.

Gene Ontology

Molecular Function

• GO:0004326 tetrahydrofolylpolyglutamate synthase activity
• GO:0005524 ATP binding
• GO:0008841 dihydrofolate synthase activity
• GO:0016874 ligase activity
• GO:0016881 acid-amino acid ligase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006730 one-carbon metabolic process
• GO:0006761 dihydrofolate biosynthetic process
• GO:0009058 biosynthetic process
• GO:0009396 folic acid-containing compound biosynthetic process
• GO:0046901 tetrahydrofolylpolyglutamate biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:1fgs, PDBe:1fgs, PDBj:1fgs
• PDBsum: 1fgs
• PubMed: 9618466
• UniProt: P15925|FPGS_LACCA Folylpolyglutamate synthase (Gene Name=fpgS)