Structure of PDB 1fbt Chain A Binding Site BS01

Receptor Information

>1fbt Chain A (length=190) Species: 10116 (Rattus norvegicus)

RSIYLCRHGESELNLRGRIGGDSGLSARGKQYAYALANFIRSQGISSLKV
WTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFA
LRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLL
AYFLDKSSDELPYLKCPLHTVLKLTPVAYGCRVESIYLNV

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 1fbt Chain A Residue 300

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1fbt Crystal structure of the rat liver fructose-2,6-bisphosphatase based on selenomethionine multiwavelength anomalous dispersion phases.
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): R7 H8 R57 E77 H142 Q143
• Binding residue (residue number reindexed from 1): R7 H8 R57 E77 H142 Q143
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): R7 H8 N14 R57 E77 H142
• Catalytic site (residue number reindexed from 1): R7 H8 N14 R57 E77 H142
• Enzyme Commision number: 2.7.1.105: 6-phosphofructo-2-kinase.
  3.1.3.46: fructose-2,6-bisphosphate 2-phosphatase.

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0005524 ATP binding

Biological Process

• GO:0006003 fructose 2,6-bisphosphate metabolic process

External links

• PDB: RCSB:1fbt, PDBe:1fbt, PDBj:1fbt
• PDBsum: 1fbt
• PubMed: 8634242
• UniProt: P07953|F261_RAT 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (Gene Name=Pfkfb1)