Structure of PDB 1f7u Chain A Binding Site BS01

Receptor Information
>1f7u Chain A (length=606) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASTANMISQLKKLSIAEPAVAKDSHPDVNIVDLMRNYISQELSKISGVDS
SLIFPALEWTNTMERGDLLIPIPRLRIKGANPKDLAVQWAEKFPCGDFLE
KVEANGPFIQFFFNPQFLAKLVIPDILTRKEDYGSCKLVENKKVIIEFSS
PNIAKPFHAGHLRSTIIGGFLANLYEKLGWEVIRMNYLGDWGKQFGLLAV
GFERYGNEEALVKDPIHHLFDVYVRINKDIEEEGDSIPLEQSTNGKAREY
FKRMEDGDEEALKIWKRFREFSIEKYIDTYARLNIKYDVYSGESQVSKES
MLKAIDLFKEKGLTHEDKGAVLIDLTKFNKKLGKAIVQKSDGTTLYLTRD
VGAAMDRYEKYHFDKMIYVIASQQDLHAAQFFEILKQMGFEWAKDLQHVN
FGMVQGMSTRKGTVVFLDNILEETKEKMHEVMKKNENKYAQIEHPEEVAD
LVGISAVMIQDMQGKRINNYEFKWERMLSFEGDTGPYLQYAHSRLRSVER
NASGITQEKWINADFSLLKEPAAKLLIRLLGQYPDVLRNAIKTHEPTTVV
TYLFKLTHQVSSCYDVLWVAGQTEELATARLALYGAARQVLYNGMRLLGL
TPVERM
Ligand information
>1f7u Chain B (length=76) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuccucguggcccaauggucacggcgucuggcuacgaaccagaagauucc
agguucaaguccuggcggggaagcca
<<<<<<<..<<<..........>>>.<<<<<.......>>>>>.....<<
<<<.......>>>>>>>>>>>>....
Receptor-Ligand Complex Structure
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PDB1f7u tRNA aminoacylation by arginyl-tRNA synthetase: induced conformations during substrates binding
Resolution2.2 Å
Binding residue
(original residue number in PDB)		E59 W60 R66 P72 P74 R75 R77 N106 F109 Q111 N153 E294 K319 K332 I337 K340 S341 L346 Y347 R350 Q374 Q375 L377 M404 Q406 V432 K439 K466 N469 F481 G483 D484 Y488 Y491 R495 S498 N502 S562 S563 Y565 D566 L568 W569 V570 A571 M607
Binding residue
(residue number reindexed from 1)		E58 W59 R65 P71 P73 R74 R76 N105 F108 Q110 N152 E293 K318 K331 I336 K339 S340 L345 Y346 R349 Q373 Q374 L376 M403 Q405 V431 K438 K465 N468 F480 G482 D483 Y487 Y490 R494 S497 N501 S561 S562 Y564 D565 L567 W568 V569 A570 M606
Enzymatic activity
Catalytic site (original residue number in PDB) K156 H159 H162
Catalytic site (residue number reindexed from 1) K155 H158 H161
Enzyme Commision number 6.1.1.19: arginine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004814 arginine-tRNA ligase activity
GO:0005524 ATP binding
GO:1990825 sequence-specific mRNA binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006420 arginyl-tRNA aminoacylation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1f7u, PDBe:1f7u, PDBj:1f7u
PDBsum1f7u
PubMed11060012
UniProtQ05506|SYRC_YEAST Arginine--tRNA ligase, cytoplasmic (Gene Name=YDR341C)

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