Structure of PDB 1f7l Chain A Binding Site BS01

Receptor Information

>1f7l Chain A (length=118) Species: 1423 (Bacillus subtilis)

GIYGIGLDITELKRIASMAGRQKRFAERILTRSELDQYYELSEKRKNEFL
AGRFAAKEAFSKAFGTGIGRQLSFQDIEIRKDQNGKPYIICTKLSPAAVH
VSITHTKEYAAAQVVIER

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 1f7l Chain A Residue 130

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1f7l Crystal structures of substrate binding to Bacillus subtilis holo-(acyl carrier protein) synthase reveal a novel trimeric arrangement of molecules resulting in three active sites.
• Resolution: 1.5 Å
• Binding residue (original residue number in PDB): D8 E58
• Binding residue (residue number reindexed from 1): D8 E58
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): K62 H105
• Catalytic site (residue number reindexed from 1): K62 H105
• Enzyme Commision number: 2.7.8.7: holo-[acyl-carrier-protein] synthase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0008897 holo-[acyl-carrier-protein] synthase activity
• GO:0016740 transferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006633 fatty acid biosynthetic process
• GO:0019878 lysine biosynthetic process via aminoadipic acid

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:1f7l, PDBe:1f7l, PDBj:1f7l
• PDBsum: 1f7l
• PubMed: 10997907
• UniProt: P96618|ACPS_BACSU Holo-[acyl-carrier-protein] synthase (Gene Name=acpS)