Structure of PDB 1f5t Chain A Binding Site BS01

Receptor Information
>1f5t Chain A (length=120) Species: 1717 (Corynebacterium diphtheriae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KDLVDTTEMYLRTIYELEEEGVTPLRARIAERLEQSGPTVSQTVARMERD
GLVVVASDRSLQMTPTGRTLATAVMRKHRLAERLLTDIIGLDINKVHDEA
DRWEHVMSDEVERRLVKVLK
Ligand information
>1f5t Chain E (length=43) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aacatgcaaggctaaggttagcctaaccttagccttgcatgtt
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1f5t Methyl groups of thymine bases are important for nucleic acid recognition by DtxR.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		R1027 A1028 R1029 S1042 R1060
Binding residue
(residue number reindexed from 1)		R26 A27 R28 S41 R59
Binding affinityPDBbind-CN: Kd=460nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0046914 transition metal ion binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:1f5t, PDBe:1f5t, PDBj:1f5t
PDBsum1f5t
PubMed10956029
UniProtP0DJL7|DTXR_CORDI Diphtheria toxin repressor (Gene Name=dtxR)

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