Structure of PDB 1f59 Chain A Binding Site BS01

Receptor Information

>1f59 Chain A (length=440) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNS
QVARVAAGLQIKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLHTLG
TETYRPSSASQCVAGIACAEIPVNQWPELIPQLVANVTNPNSTEHMKEST
LEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLN
SLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQNLVKIMSLYYQ
YMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEA
AEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGV
CLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPS
QLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLP

Ligand information

>1f59 Chain C (length=22) Species: 4932 (Saccharomyces cerevisiae) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

DDSKPAFSFGAAAAAAAAAFSF

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1f59 Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking.
Resolution	2.8 Å
Binding residue (original residue number in PDB)	N171 L174 T175 I178 Q179 R182 K211 S213 E214 H216 F217 I218 M219 Q220 C223 E224 Y255 A259 I263
Binding residue (residue number reindexed from 1)	N171 L174 T175 I178 Q179 R182 K211 S213 E214 H216 F217 I218 M219 Q220 C223 E224 Y255 A259 I263

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0031267	small GTPase binding

	Biological Process
GO:0006606	protein import into nucleus
GO:0006886	intracellular protein transport

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Molecular Function

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Biological Process

External links

PDB	RCSB:1f59, PDBe:1f59, PDBj:1f59
PDBsum	1f59
PubMed	10929717
UniProt	Q14974\|IMB1_HUMAN Importin subunit beta-1 (Gene Name=KPNB1)

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