Structure of PDB 1f1j Chain A Binding Site BS01

Receptor Information
>1f1j Chain A (length=230) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFD
VIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVT
PIKDLTAHFRGDRSKTLLEKPKLFFIQACRGTELDDGIQKIPVEADFLFA
YSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARH
FESQSDDPHFHEKKQIPCVVSMLTKELYFS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1f1j The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity.
Resolution2.35 Å
Binding residue
(original residue number in PDB)		R87 S143 H144 Q184 C186 Y230 S231 W232 R233 P235 S275 Q276
Binding residue
(residue number reindexed from 1)		R30 S86 H87 Q127 C129 Y158 S159 W160 R161 P163 S203 Q204
Enzymatic activity
Catalytic site (original residue number in PDB) G85 V86 G145 C186
Catalytic site (residue number reindexed from 1) G28 V29 G88 C129
Enzyme Commision number 3.4.22.60: caspase-7.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004190 aspartic-type endopeptidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0007507 heart development
GO:0009411 response to UV
GO:0016485 protein processing
GO:0030163 protein catabolic process
GO:0042742 defense response to bacterium
GO:0043525 positive regulation of neuron apoptotic process
GO:0044346 fibroblast apoptotic process
GO:0051146 striated muscle cell differentiation
GO:0051402 neuron apoptotic process
GO:0051604 protein maturation
GO:0070227 lymphocyte apoptotic process
GO:0071222 cellular response to lipopolysaccharide
GO:0071887 leukocyte apoptotic process
GO:0072734 cellular response to staurosporine
GO:0097194 execution phase of apoptosis
GO:1905686 positive regulation of plasma membrane repair
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:1f1j, PDBe:1f1j, PDBj:1f1j
PDBsum1f1j
PubMed10873833
UniProtP55210|CASP7_HUMAN Caspase-7 (Gene Name=CASP7)

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