Structure of PDB 1ezw Chain A Binding Site BS01

Receptor Information
>1ezw Chain A (length=347) Species: 2320 (Methanopyrus kandleri) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AEVSFGIELLPDDKPTKIAHLIKVAEDNGFEYAWICDHYNNYSYMGVLTL
AAVITSKIKLGPGITNPYTRHPLITASNIATLDWISGGRAIIGMGPGDKA
TFDKMGLPFPCKIPIWNPEAEDEVGPATAIREVKEVIYQYLEGGPVEYEG
KYVKTGTADVKARSIQGSDIPFYMGAQGPIMLKTAGEIANGVLVNASNPK
DFEVAVPKIEEGAKEAGRSLDEIDVAAYTCFSIDKDEDKAIEATKIVVAF
IVMGSPDVVLERHGIDTEKAEQIAEAIGKGDFGTAIGLVDEDMIEAFSIA
GDPDTVVDKIEELLKAGVTQVVVGSPIGPDKEKAIELVGQEVIPHFK
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain1ezw Chain A Residue 361 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1ezw Structure of coenzyme F(420) dependent methylenetetrahydromethanopterin reductase from two methanogenic archaea.
Resolution1.65 Å
Binding residue
(original residue number in PDB)		T56 S57
Binding residue
(residue number reindexed from 1)		T55 S56
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H39 D99
Catalytic site (residue number reindexed from 1) H38 D98
Enzyme Commision number 1.5.98.2: 5,10-methylenetetrahydromethanopterin reductase.
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0018537 coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity
Biological Process
GO:0006730 one-carbon metabolic process
GO:0015948 methanogenesis
GO:0019386 methanogenesis, from carbon dioxide
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1ezw, PDBe:1ezw, PDBj:1ezw
PDBsum1ezw
PubMed10891279
UniProtQ8TXY4|MER_METKA 5,10-methylenetetrahydromethanopterin reductase (Gene Name=mer)

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