Structure of PDB 1exz Chain A Binding Site BS01

Receptor Information
>1exz Chain A (length=133) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CRNRVTNNVKDVTKLVANLPKDYMITLKYVPGMDVLPSHCWISEMVVQLS
DSLTDLLDKFSNISEGLSNYSIIDKLVNIVDDLVECVKENSSKDLKKSFK
SPEPRLFTPEEFFRIFNRSIDAFKDFVVASDCV
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1exz Chain A Residue 806 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1exz Crystal structure of human stem cell factor: implication for stem cell factor receptor dimerization and activation.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		D54 D58
Binding residue
(residue number reindexed from 1)		D51 D55
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005173 stem cell factor receptor binding
Biological Process
GO:0007155 cell adhesion
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:1exz, PDBe:1exz, PDBj:1exz
PDBsum1exz
PubMed10884405
UniProtP21583|SCF_HUMAN Kit ligand (Gene Name=KITLG)

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