Structure of PDB 1ewn Chain A Binding Site BS01

Receptor Information
>1ewn Chain A (length=200) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HLTRLGLEFFDQPAVPLARAFLGQVLVRRLPNGTELRGRIVETQAYLGPE
DEAAHSRGGRQTPRNRGMFMKPGTLYVYIIYGMYFCMNISSQGDGACVLL
RALEPLEGLETMRQLRSTVLKDRELCSGPSKLCQALAINKSFDQRDLAQD
EAVWLERGPAVVAAARVGVGHAGEWARKPLRFYVRGSPWVSVVDRVAEQD
Ligand information
Receptor-Ligand Complex Structure
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PDB1ewn Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase, AAG.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		Y127 A135 H136 M149 Y159 I161 Y162 Y165 N169 C178 R182 R197 G217 P218 S219 K220 G263
Binding residue
(residue number reindexed from 1)		Y46 A54 H55 M68 Y78 I80 Y81 Y84 N88 C97 R101 R116 G128 P129 S130 K131 G168
Enzymatic activity
Enzyme Commision number 3.2.2.21: DNA-3-methyladenine glycosylase II.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0003905 alkylbase DNA N-glycosylase activity
Biological Process
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:1ewn, PDBe:1ewn, PDBj:1ewn
PDBsum1ewn
PubMed11106395
UniProtP29372|3MG_HUMAN DNA-3-methyladenine glycosylase (Gene Name=MPG)

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