Structure of PDB 1elt Chain A Binding Site BS01

Receptor Information

>1elt Chain A (length=236) Species: 8030 (Salmo salar)

VVGGRVAQPNSWPWQISLQYKSGSSYYHTCGGSLIRQGWVMTAAHCVDSA
RTWRVVLGEHNLNTNEGKEQIMTVNSVFIHSGWNSDDVAGGYDIALLRLN
TQASLNSAVQLAALPPSNQILPNNNPCYITGWGKTSTGGPLSDSLKQAWL
PSVDHATCSSSGWWGSTVKTTMVCAGGGANSGCNGDSGGPLNCQVNGSYY
VHGVTSFVSSSGCNASKKPTVFTRVSAYISWMNGIM

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 1elt Chain A Residue 300

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1elt Structure of native pancreatic elastase from North Atlantic salmon at 1.61 A resolution.
• Resolution: 1.61 Å
• Binding residue (original residue number in PDB): E70 N72 T75 E77 E80
• Binding residue (residue number reindexed from 1): E59 N61 T64 E66 E69
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): H57 D102 N192 G193 D194 S195 G196
• Catalytic site (residue number reindexed from 1): H45 D93 N184 G185 D186 S187 G188
• Enzyme Commision number: 3.4.21.36: pancreatic elastase.

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space

External links

• PDB: RCSB:1elt, PDBe:1elt, PDBj:1elt
• PDBsum: 1elt
• PubMed: 15299762
• UniProt: Q7SIG3|ELA1_SALSA Elastase-1