Structure of PDB 1ej9 Chain A Binding Site BS01

Receptor Information
>1ej9 Chain A (length=483) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPK
AEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCDF
TQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIAN
FKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWK
EVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKK
CVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTV
GCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQ
LFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQL
KELTAPDENIPAKILSYNRANRAVAILCNHQIALGTSKLNFLDPRITVAW
CKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF
Ligand information
Receptor-Ligand Complex Structure
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PDB1ej9 Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		H266 R364 V410 T411 W412 I424 Y426 M428 K436 K443 R488 K532 D533 I535 K587 H632 Q633 T718 F723
Binding residue
(residue number reindexed from 1)		H64 R162 V208 T209 W210 I222 Y224 M226 K234 K241 R286 K330 D331 I333 K385 H430 Q431 T436 F441
Enzymatic activity
Enzyme Commision number 5.6.2.1: DNA topoisomerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
Biological Process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1ej9, PDBe:1ej9, PDBj:1ej9
PDBsum1ej9
PubMed10841763
UniProtP11387|TOP1_HUMAN DNA topoisomerase 1 (Gene Name=TOP1)

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