Structure of PDB 1ej4 Chain A Binding Site BS01

Receptor Information

>1ej4 Chain A (length=179) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQL
SSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWL
ETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENRDAVTHIGR
VYKERLGLPPKIVIGYQSHADTATNRFVV

Ligand information

>1ej4 Chain B (length=14) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

RIIYDRKFLMECRN

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1ej4 Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G.
Resolution	2.25 Å
Binding residue (original residue number in PDB)	H37 P38 Q40 V69 W73 E132 L135 I138 G139 E140 D147
Binding residue (residue number reindexed from 1)	H6 P7 Q9 V38 W42 E101 L104 I107 G108 E109 D116

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003743	translation initiation factor activity

	Biological Process
GO:0006413	translational initiation

	Cellular Component
GO:0005737	cytoplasm

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Cellular Component

External links

PDB	RCSB:1ej4, PDBe:1ej4, PDBj:1ej4
PDBsum	1ej4
PubMed	10394359
UniProt	P63073\|IF4E_MOUSE Eukaryotic translation initiation factor 4E (Gene Name=Eif4e)

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