Structure of PDB 1eiy Chain A Binding Site BS01

Receptor Information
>1eiy Chain A (length=345) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LAAIQNARDLEELKALKARYLGKKGLLTQEMKGLSALPLEERRKRGQELN
AIKAALEAALEAREKALEEAALKEALERERVDVSLPGASLFSGGLHPITL
MERELVEIFRALGYQAVEGPEVESEFFNFDALNIPEHHPARDMWDTFWLT
GEGFRLEGPLGEEVEGRLLLRTHTSPMQVRYMVAHTPPFRIVVPGRVFRF
EQTDATHEAVFHQLEGLVVGEGIAMAHLKGAIYELAQALFGPDSKVRFQP
VYFPFVEPGAQFAVWWPEGGKWLELGGAGMVHPKVFQAVDAYRERLGLPP
AYRGVTGFAFGLGVERLAMLRYGIPDIRYFFGGRLKFLEQFKGVL
Ligand information
>1eiy Chain C (length=76) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gccgagguagcucaguugguagagcaugcgacugaaaaucgcaguguccg
cgguucgauuccgcgccucggcacca
<<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<
<<<.......>>>>>>>>>>>>....
Receptor-Ligand Complex Structure
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PDB1eiy The crystal structure of phenylalanyl-tRNA synthetase from thermus thermophilus complexed with cognate tRNAPhe.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		M148 W149 E220 G316
Binding residue
(residue number reindexed from 1)		M143 W144 E215 G311
Enzymatic activity
Catalytic site (original residue number in PDB) W149 H178 R204 Q218 V261 A314
Catalytic site (residue number reindexed from 1) W144 H173 R199 Q213 V256 A309
Enzyme Commision number 6.1.1.20: phenylalanine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004826 phenylalanine-tRNA ligase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006432 phenylalanyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1eiy, PDBe:1eiy, PDBj:1eiy
PDBsum1eiy
PubMed9016717
UniProtQ5SGX2|SYFA_THET8 Phenylalanine--tRNA ligase alpha subunit (Gene Name=pheS)

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