Structure of PDB 1ee8 Chain A Binding Site BS01

Receptor Information
>1ee8 Chain A (length=266) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PELPEVETTRRRLRPLVLGQTLRQVVHRDPARYRNTALAEGRRILEVDRR
GKFLLFALEGGVELVAHLGMTGGFRLEPTPHTRAALVLEGRTLYFHDPRR
FGRLFGVRRGDYREIPLLLRLGPEPLSEAFAFPGFFRGLKESARPLKALL
LDQRLAAGVGNIYADEALFRARLSPFRPARSLTEEEARRLYRALREVLAE
AVELGGSTLSDQSYRQPDGLPGGFQTRHAVYGREGLPCPACGRPVERRVV
AGRGTHFCPTCQGEGP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1ee8 Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1ee8 Crystal structure of a repair enzyme of oxidatively damaged DNA, MutM (Fpg), from an extreme thermophile, Thermus thermophilus HB8.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		C238 C241 C258 C261
Binding residue
(residue number reindexed from 1)		C238 C241 C258 C261
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) P1 E2
Catalytic site (residue number reindexed from 1) P1 E2
Enzyme Commision number 3.2.2.23: DNA-formamidopyrimidine glycosylase.
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0008270 zinc ion binding
GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity
GO:0016787 hydrolase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0016829 lyase activity
GO:0019104 DNA N-glycosylase activity
GO:0034039 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
GO:0046872 metal ion binding
GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1ee8, PDBe:1ee8, PDBj:1ee8
PDBsum1ee8
PubMed10921868
UniProtO50606|FPG_THET8 Formamidopyrimidine-DNA glycosylase (Gene Name=mutM)

[Back to BioLiP]