Structure of PDB 1edh Chain A Binding Site BS01

Receptor Information
>1edh Chain A (length=211) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VIPPISCPENEKGEFPKNLVQIKSNRDKETKVFYSITGQGADKPPVGVFI
IERETGWLKVTQPLDREAIAKYILYSHAVSSNGEAVEDPMEIVITVTDQN
DNRPEFTQEVFEGSVAEGAVPGTSVMKVSATDADDDVNTYNAAIAYTIVS
QDPELPHKNMFTVNRDTGVISVLTSGLDRESYPTYTLVVQAADLQGEGLS
TTAKAVITVKD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1edh Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1edh Structural basis of calcium-induced E-cadherin rigidification and dimerization.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		N102 N104 D134 D136 N143 D195
Binding residue
(residue number reindexed from 1)		N100 N102 D132 D134 N141 D193
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0098609 cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1edh, PDBe:1edh, PDBj:1edh
PDBsum1edh
PubMed8598933
UniProtP09803|CADH1_MOUSE Cadherin-1 (Gene Name=Cdh1)

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