Structure of PDB 1dxi Chain A Binding Site BS01

Receptor Information

>1dxi Chain A (length=388) Species: 33900 (Streptomyces murinus)

MSFQPTPEDRFTFGLWTVGWQGRDPFGDATRPALDPVETVQRLAELGAYG
VTFHDDDLIPFGSSDTERESHIKRFRQALDATGMTVPMATTNLFTHPVFK
DGGFTANDRDVRRYALRKTIGNIDLAAELGAKTYVAWGGREGAESGGAKD
VRDALDRMKEAFDLLGEYVTAQGYDLRFAIEPKPNEPRGDILLPTVGHAL
AFIERLERPELYGVNPEVGHEQMAGLNFPHGIAQALWAGKLFHIDLNGQS
GIKYDQDLRFGAGDLRAAFWLVDLLETAGYEGPRHFDFKPPRTEDFDGVW
ASAAGCMRNYLILKDRAAAFRADPEVQEALRAARLDQLAQPTAADGLDAL
LADRAAFEDFDVDAAAARGMAFEHLDQLAMDHLLGARG

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 1dxi Chain A Residue 389

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1dxi Structure determination of glucose isomerase from Streptomyces murinus at 2.6 A resolution.
• Resolution: 2.6 Å
• Binding residue (original residue number in PDB): E181 E217 D245 D287
• Binding residue (residue number reindexed from 1): E181 E217 D245 D287
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): H54 D57 M88 E181 K183 E217 H220 D245 D255 D257 D287
• Catalytic site (residue number reindexed from 1): H54 D57 M88 E181 K183 E217 H220 D245 D255 D257 D287
• Enzyme Commision number: 5.3.1.5: xylose isomerase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0009045 xylose isomerase activity
• GO:0016853 isomerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0042732 D-xylose metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:1dxi, PDBe:1dxi, PDBj:1dxi
• PDBsum: 1dxi
• PubMed: 15299450
• UniProt: P37031|XYLA_STRMR Xylose isomerase (Gene Name=xylA)