Structure of PDB 1dko Chain A Binding Site BS01

Receptor Information

>1dko Chain A (length=410) Species: 562 (Escherichia coli)

QSEPELKLESVVIVSRHGVRAPTKATQLMQDVTPDAWPTWPVKLGWLTPR
GGELIAYLGHYQRQRLVADGLLAKKGCPQSGQVAIIADVDERTRKTGEAF
AAGLAPDCAITVHTQTDTSSPDPLFNPLKTGVCQLDNANVTDAILSRAGG
SIADFTGHRQTAFRELERVLNFPQSNLCLKREKQDESCSLTQALPSELKV
SADNVSLTGAVSLASMLTEIFLLQQAQGMPEPGWGRITDSHQWNTLLSLH
NAQFYLLQRTPEVARSRATPLLDLIKTALTPHPPQKQAYGVTLPTSVLFI
AGHDTNLANLGGALELNWTLPGQPDNTPPGGELVFERWRRLSDNSQWIQV
SLVFQTLQQMRDKTPLSLNTPPGEVKLTLAGCEERNAQGMCSLAGFTQIV
NEARIPACSL

Ligand information

• Ligand ID: WO4
• InChI: InChI=1S/4O.W/q;;2*-1;
• InChIKey: PBYZMCDFOULPGH-UHFFFAOYSA-N
• SMILES:
  OpenEye OEToolkits 1.5.0: [O-][W](=O)(=O)[O-]
  ACDLabs 10.04
  CACTVS 3.341: [O-][W]([O-])(=O)=O
• Formula: O4 W
• Name: TUNGSTATE(VI)ION
• PDB chain: 1dko Chain A Residue 504

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1dko Crystal structures of Escherichia coli phytase and its complex with phytate.
• Resolution: 2.38 Å
• Binding residue (original residue number in PDB): R16 H17 R20 R92 H303 D304
• Binding residue (residue number reindexed from 1): R16 H17 R20 R92 H303 D304
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.1.3.-
  3.6.1.-

Gene Ontology

Molecular Function

• GO:0003924 GTPase activity
• GO:0003993 acid phosphatase activity
• GO:0008252 nucleotidase activity
• GO:0008707 4-phytase activity
• GO:0016787 hydrolase activity
• GO:0050308 sugar-phosphatase activity
• GO:0052745 inositol phosphate phosphatase activity

Biological Process

• GO:0016036 cellular response to phosphate starvation
• GO:0071454 cellular response to anoxia

Cellular Component

• GO:0030288 outer membrane-bounded periplasmic space
• GO:0042597 periplasmic space

External links

• PDB: RCSB:1dko, PDBe:1dko, PDBj:1dko
• PDBsum: 1dko
• PubMed: 10655611
• UniProt: P07102|PPA_ECOLI Phytase AppA (Gene Name=appA)