Structure of PDB 1d8i Chain A Binding Site BS01

Receptor Information

>1d8i Chain A (length=288) Species: 4932 (Saccharomyces cerevisiae)

HMYRNVPIWAQKWKPTIKALQSINVKDLKIDPSFLNIIPDDDLTKSVQDW
VYATIYSIAPELRSFIELEMKFGVIIDAKGPDRVNPPVSSQCVFTELDAH
LTPNIDASLFKELSKYIRGISEVTENTGKFSIIESQTRDSVYRVGPRFLR
MSTDIKTGRVGQFIEKRHVAQLLLYSPKDSYDVKISLNLELPVPDNDPPE
KYKSQSPISERTKDRVSYIHNDSCTRIDITKVENHSETTHEVELEINTPA
LLNAFDNITNDSKEYASLIRTFLNNGTIIRRKLSSLSY

Ligand information

• Ligand ID: SO4
• InChI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
• InChIKey: QAOWNCQODCNURD-UHFFFAOYSA-L
• SMILES:
  OpenEye OEToolkits 1.5.0: [O-]S(=O)(=O)[O-]
  CACTVS 3.341: [O-][S]([O-])(=O)=O
  ACDLabs 10.04: [O-]S([O-])(=O)=O
• Formula: O4 S
• Name: SULFATE ION
• DrugBank: DB14546
• PDB chain: 1d8i Chain A Residue 601

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1d8i Structure and mechanism of yeast RNA triphosphatase: an essential component of the mRNA capping apparatus.
• Resolution: 2.05 Å
• Binding residue (original residue number in PDB): K456 R458
• Binding residue (residue number reindexed from 1): K213 R215
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): E305 E307 R393 K409 K456 E496
• Catalytic site (residue number reindexed from 1): E67 E69 R150 K166 K213 E245
• Enzyme Commision number: 3.6.1.74: mRNA 5'-phosphatase.

Gene Ontology

Molecular Function

• GO:0004651 polynucleotide 5'-phosphatase activity

External links

• PDB: RCSB:1d8i, PDBe:1d8i, PDBj:1d8i
• PDBsum: 1d8i
• PubMed: 10589681
• UniProt: O13297|CET1_YEAST mRNA-capping enzyme subunit beta (Gene Name=CET1)