Structure of PDB 1d4w Chain A Binding Site BS01

Receptor Information

>1d4w Chain A (length=104) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MDAVAVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGY
IYTYRVSQTETGSWSAETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQY
PVEK

Ligand information

>1d4w Chain C (length=10) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

SLTIYAQVQK

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1d4w Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.
Resolution	1.8 Å
Binding residue (original residue number in PDB)	R13 E17 R32 S34 E35 S36 C42 Y50 I51 Y52 T53 Y54 R55 E67 T68 A69 V72 R75 D91 G93
Binding residue (residue number reindexed from 1)	R13 E17 R32 S34 E35 S36 C42 Y50 I51 Y52 T53 Y54 R55 E67 T68 A69 V72 R75 D91 G93

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Biological Process
GO:0006968	cellular defense response
GO:0007267	cell-cell signaling

	Cellular Component
GO:0005737	cytoplasm

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Biological Process

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Cellular Component

External links

PDB	RCSB:1d4w, PDBe:1d4w, PDBj:1d4w
PDBsum	1d4w
PubMed	10549287
UniProt	O60880\|SH21A_HUMAN SH2 domain-containing protein 1A (Gene Name=SH2D1A)

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