Structure of PDB 1d1q Chain A Binding Site BS01

Receptor Information
>1d1q Chain A (length=159) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IEKPKISVAFIALGNFCRSPMAEAIFKHEVEKANLENRFNKIDSFGTSNY
HVGESPDHRTVSICKQHGVKINHKGKQIKTKHFDEYDYIIGMDESNINNL
KKIQPEGSKAKVCLFGDWNTNDGTVQTIIEDPWYGDIQDFEYNFKQITYF
SKQFLKKEL
Ligand information
Ligand ID4NP
InChIInChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)
InChIKeyXZKIHKMTEMTJQX-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341O[P](O)(=O)Oc1ccc(cc1)[N+]([O-])=O
ACDLabs 10.04O=P(Oc1ccc(cc1)[N+]([O-])=O)(O)O
OpenEye OEToolkits 1.5.0c1cc(ccc1[N+](=O)[O-])OP(=O)(O)O
FormulaC6 H6 N O6 P
Name4-NITROPHENYL PHOSPHATE
ChEMBLCHEMBL24231
DrugBankDB04214
ZINCZINC000001529638
PDB chain1d1q Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1d1q Crystal structures of a low-molecular weight protein tyrosine phosphatase from Saccharomyces cerevisiae and its complex with the substrate p-nitrophenyl phosphate.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		A13 L14 G15 N16 F17 C18 R19 D132 W134
Binding residue
(residue number reindexed from 1)		A12 L13 G14 N15 F16 C17 R18 D131 W133
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) A13 N16 C18 R19 S20 D132
Catalytic site (residue number reindexed from 1) A12 N15 C17 R18 S19 D131
Enzyme Commision number 3.1.3.2: acid phosphatase.
3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0003993 acid phosphatase activity
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1d1q, PDBe:1d1q, PDBj:1d1q
PDBsum1d1q
PubMed10684639
UniProtP40347|PPAL_YEAST Low molecular weight phosphotyrosine protein phosphatase (Gene Name=LTP1)

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