Structure of PDB 1czz Chain A Binding Site BS01

Receptor Information
>1czz Chain A (length=187) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTYDGVFIWKISDFPRK
RQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVM
KGPNDALLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSSSFQRPVNDMN
IASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVDLTGL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1czz The structural basis for the recognition of diverse receptor sequences by TRAF2.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		R393 Y395 D399 G400 F410 F447 R448 S455 I465 A466 S467 G468
Binding residue
(residue number reindexed from 1)		R79 Y81 D85 G86 F96 F133 R134 S141 I151 A152 S153 G154
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005164 tumor necrosis factor receptor binding
Biological Process
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042981 regulation of apoptotic process
GO:0046328 regulation of JNK cascade
GO:0051865 protein autoubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:1czz, PDBe:1czz, PDBj:1czz
PDBsum1czz
PubMed10518213
UniProtQ12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Gene Name=TRAF2)

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