Structure of PDB 1czy Chain A Binding Site BS01

Receptor Information
>1czy Chain A (length=168) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AMADLEQKVLEMEASTYDGVFIWKISDFPRKRQEAVAGRIPAIFSPAFYT
SRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLM
LLDQNNREHVIDAFRPDVTSSSFQRPVNDMNIASGCPLFCPVSKMEAKNS
YVRDDAIFIKAIVDLTGL
Ligand information
>1czy Chain D (length=7) Species: 10377 (Human herpesvirus 4 strain B95-8) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PQQATDD
Receptor-Ligand Complex Structure
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PDB1czy The structural basis for the recognition of diverse receptor sequences by TRAF2.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		R393 Y395 D399 F410 F447 R448 S455 I465 A466 S467 G468 P470
Binding residue
(residue number reindexed from 1)		R60 Y62 D66 F77 F114 R115 S122 I132 A133 S134 G135 P137
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005164 tumor necrosis factor receptor binding
Biological Process
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042981 regulation of apoptotic process
GO:0046328 regulation of JNK cascade
GO:0051865 protein autoubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:1czy, PDBe:1czy, PDBj:1czy
PDBsum1czy
PubMed10518213
UniProtQ12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Gene Name=TRAF2)

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