Structure of PDB 1cwt Chain A Binding Site BS01

Receptor Information
>1cwt Chain A (length=177) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVI
VDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHC
EFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFC
EPQDYRPMNHEAFKDELKTFRLKTRSW
Ligand information
Ligand IDSO4
InChIInChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
InChIKeyQAOWNCQODCNURD-UHFFFAOYSA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[O-]S(=O)(=O)[O-]
CACTVS 3.341[O-][S]([O-])(=O)=O
ACDLabs 10.04[O-]S([O-])(=O)=O
FormulaO4 S
NameSULFATE ION
ChEMBL
DrugBankDB14546
ZINC
PDB chain1cwt Chain A Residue 552 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1cwt Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		C473 E474 F475 S477 E478 R479 W550
Binding residue
(residue number reindexed from 1)		C100 E101 F102 S104 E105 R106 W177
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:1902751 positive regulation of cell cycle G2/M phase transition

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:1cwt, PDBe:1cwt, PDBj:1cwt
PDBsum1cwt
PubMed10543950
UniProtP30305|MPIP2_HUMAN M-phase inducer phosphatase 2 (Gene Name=CDC25B)

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