Structure of PDB 1cwe Chain A Binding Site BS01
Receptor Information
>1cwe Chain A (length=98) Species:
9606
(Homo sapiens) [
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GSWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQ
GEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSR
Ligand information
>1cwe Chain B (length=6) Species:
32630
(synthetic construct) [
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QFEEIP
Receptor-Ligand Complex Structure
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PDB
1cwe
The crystal structures of the SH2 domain of p56lck complexed with two phosphopeptides suggest a gated peptide binding site.
Resolution
2.3 Å
Binding residue
(original residue number in PDB)
R12 R32 S42 H58 Y59 I71 S72 R74
Binding residue
(residue number reindexed from 1)
R10 R30 S40 H56 Y57 I69 S70 R72
Enzymatic activity
Enzyme Commision number
2.7.10.2
: non-specific protein-tyrosine kinase.
External links
PDB
RCSB:1cwe
,
PDBe:1cwe
,
PDBj:1cwe
PDBsum
1cwe
PubMed
7532720
UniProt
P06239
|LCK_HUMAN Tyrosine-protein kinase Lck (Gene Name=LCK)
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