Structure of PDB 1cvl Chain A Binding Site BS01

Receptor Information
>1cvl Chain A (length=316) Species: 42739 (Chromobacterium viscosum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ADTYAATRYPVILVHGLAGTDKFANVVDYWYGIQSDLQSHGAKVYVANLS
GFQSDDGPNGRGEQLLAYVKQVLAATGATKVNLIGHSQGGLTSRYVAAVA
PQLVASVTTIGTPHRGSEFADFVQDVLKTDPTGLSSTVIAAFVNVFGTLV
SSSHNTDQDALAALRTLTTAQTATYNRNFPSAGLGAPGSCQTGAATETVG
GSQHLLYSWGGTAIQPTSTVTGATDTSTGTLDVANVTDPSTLALLATGAV
MINRASGQNDGLVSRCSSLFGQVISTSYHWNHLDEINQLLGVRGANAEDP
VAVIRTHVNRLKLQGV
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1cvl Chain A Residue 320 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1cvl Crystal structure of a bacterial lipase from Chromobacterium viscosum ATCC 6918 refined at 1.6 angstroms resolution.
Resolution1.6 Å
Binding residue
(original residue number in PDB)		D241 D287 Q291 V295
Binding residue
(residue number reindexed from 1)		D238 D284 Q288 V292
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) L17 S87 Q88 D241 D263 H285 D287 Q291 V295
Catalytic site (residue number reindexed from 1) L17 S87 Q88 D238 D260 H282 D284 Q288 V292
Enzyme Commision number 3.1.1.3: triacylglycerol lipase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004806 triacylglycerol lipase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0016042 lipid catabolic process
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1cvl, PDBe:1cvl, PDBj:1cvl
PDBsum1cvl
PubMed8683577
UniProtP0DUB9|LIP_PSEPS Triacylglycerol lipase (Gene Name=lip)

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