Structure of PDB 1cm4 Chain A Binding Site BS01

Receptor Information

>1cm4 Chain A (length=143) Species: 9913 (Bos taurus)

LTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMIN
EVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAA
ELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMT

Ligand information

>1cm4 Chain B (length=18) Species: 10116 (Rattus norvegicus)

FNARRKLKGAILTTMLAT

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1cm4 Motions of calmodulin characterized using both Bragg and diffuse X-ray scattering.
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): E7 A10 E11 E14 A15 M36 M72 E84 E87 A88 F92 E120 E123 M124 E127 F141 M144 M145
• Binding residue (residue number reindexed from 1): E4 A7 E8 E11 A12 M33 M69 E81 E84 A85 F89 E117 E120 M121 E124 F138 M141 M142

Enzymatic activity

• Catalytic site (original residue number in PDB): V35
• Catalytic site (residue number reindexed from 1): V32

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding
• GO:0005515 protein binding
• GO:0019904 protein domain specific binding
• GO:0046872 metal ion binding

Biological Process

• GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
• GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
• GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity

Cellular Component

• GO:0000922 spindle pole
• GO:0005737 cytoplasm
• GO:0005819 spindle
• GO:0005829 cytosol
• GO:0005856 cytoskeleton
• GO:0032991 protein-containing complex

External links

• PDB: RCSB:1cm4, PDBe:1cm4, PDBj:1cm4
• PDBsum: 1cm4
• PubMed: 9438860
• UniProt: P62157|CALM_BOVIN Calmodulin (Gene Name=CALM)