Structure of PDB 1cm1 Chain A Binding Site BS01

Receptor Information

>1cm1 Chain A (length=143) Species: 9913 (Bos taurus)

LTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMIN
EVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAA
ELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMT

Ligand information

>1cm1 Chain B (length=18) Species: 9913 (Bos taurus)

FNARRKLKGAILTTMLAT

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1cm1 Motions of calmodulin characterized using both Bragg and diffuse X-ray scattering.
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): E7 E11 F12 E14 A15 L18 F19 M36 E84 F92 E120 M124 F141 M144 M145
• Binding residue (residue number reindexed from 1): E4 E8 F9 E11 A12 L15 F16 M33 E81 F89 E117 M121 F138 M141 M142

Enzymatic activity

• Catalytic site (original residue number in PDB): V35
• Catalytic site (residue number reindexed from 1): V32

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding
• GO:0005515 protein binding
• GO:0019904 protein domain specific binding
• GO:0046872 metal ion binding

Biological Process

• GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
• GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
• GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity

Cellular Component

• GO:0000922 spindle pole
• GO:0005737 cytoplasm
• GO:0005819 spindle
• GO:0005829 cytosol
• GO:0005856 cytoskeleton
• GO:0032991 protein-containing complex

External links

• PDB: RCSB:1cm1, PDBe:1cm1, PDBj:1cm1
• PDBsum: 1cm1
• PubMed: 9438860
• UniProt: P62157|CALM_BOVIN Calmodulin (Gene Name=CALM)