Structure of PDB 1cit Chain A Binding Site BS01

Receptor Information

>1cit Chain A (length=89) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKSAKYICLANKDCPVDKR
RRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKP

Ligand information

>1cit Chain B (length=16) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ccgaaaaggtcatgcg

Receptor-Ligand Complex Structure

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PDB	1cit DNA-binding mechanism of the monomeric orphan nuclear receptor NGFI-B.
Resolution	2.7 Å
Binding residue (original residue number in PDB)	Q242 H243 Y244 K253 V302 R303 G309 R310 R311 G312 R313
Binding residue (residue number reindexed from 1)	Q13 H14 Y15 K24 V73 R74 G80 R81 R82 G83 R84
Binding affinity	PDBbind-CN: Kd=1nM

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003700	DNA-binding transcription factor activity
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

	Biological Process
GO:0006355	regulation of DNA-templated transcription

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Molecular Function

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Biological Process

External links

PDB	RCSB:1cit, PDBe:1cit, PDBj:1cit
PDBsum	1cit
PubMed	10331876
UniProt	P22829\|NR4A1_RAT Nuclear receptor subfamily 4 group A member 1 (Gene Name=Nr4a1)

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