Structure of PDB 1cf0 Chain A Binding Site BS01

Receptor Information
>1cf0 Chain A (length=138) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GWNAYIDNLMADGTCQDAAIVGYKDSPSVWAAVPGKTFVNITPAEVGVLV
GKDRSSFYVNGLTLGGQKCSVIRDSLLQDGEFSMDLRTKSTGGAPTFNVT
VTKTDKTLVLLMGKEGVHGGLINKKCYEMASHLRRSQY
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1cf0 Profilin binds proline-rich ligands in two distinct amide backbone orientations.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		G2 W3 Y6 W31 M130 H133 Y139
Binding residue
(residue number reindexed from 1)		G1 W2 Y5 W30 M129 H132 Y138
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000774 adenyl-nucleotide exchange factor activity
GO:0001784 phosphotyrosine residue binding
GO:0003723 RNA binding
GO:0003779 actin binding
GO:0003785 actin monomer binding
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0031267 small GTPase binding
GO:0045296 cadherin binding
GO:0070064 proline-rich region binding
Biological Process
GO:0001843 neural tube closure
GO:0006357 regulation of transcription by RNA polymerase II
GO:0010634 positive regulation of epithelial cell migration
GO:0030036 actin cytoskeleton organization
GO:0030833 regulation of actin filament polymerization
GO:0030837 negative regulation of actin filament polymerization
GO:0030838 positive regulation of actin filament polymerization
GO:0032232 negative regulation of actin filament bundle assembly
GO:0032233 positive regulation of actin filament bundle assembly
GO:0032781 positive regulation of ATP-dependent activity
GO:0044087 regulation of cellular component biogenesis
GO:0050804 modulation of chemical synaptic transmission
GO:0050821 protein stabilization
GO:0051497 negative regulation of stress fiber assembly
GO:0060074 synapse maturation
GO:0098885 modification of postsynaptic actin cytoskeleton
GO:0110053 regulation of actin filament organization
GO:1900029 positive regulation of ruffle assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0016020 membrane
GO:0070062 extracellular exosome
GO:0072562 blood microparticle
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1cf0, PDBe:1cf0, PDBj:1cf0
PDBsum1cf0
PubMed10404225
UniProtP07737|PROF1_HUMAN Profilin-1 (Gene Name=PFN1)

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