Structure of PDB 1c0g Chain A Binding Site BS01
Receptor Information
>1c0g Chain A (length=368) Species:
44689
(Dictyostelium discoideum) [
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DGEDVQALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHTGKDSYVGDE
AQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTE
APLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGD
GVSHTVPIYEGYALPHAILRLDLAGRDLTDYMMKILTERGYSFTTTAERE
IVRDIKEKLAYVALDFEAEMKAYASSSALEKSYELPDGQVITIGNERFRC
PEALFQPSFLGMESAGIHETTYNSIMKCDVDIRKDLYGNVVLSGGTTMFP
GIADRMNKELTALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWI
SKHEYDESGPSIVHRKCF
Ligand information
Ligand ID
ATP
InChI
InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKey
ZKHQWZAMYRWXGA-KQYNXXCUSA-N
SMILES
Software
SMILES
OpenEye OEToolkits 1.5.0
c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341
Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04
O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
OpenEye OEToolkits 1.5.0
c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341
Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@](O)(=O)O[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
Formula
C10 H16 N5 O13 P3
Name
ADENOSINE-5'-TRIPHOSPHATE
ChEMBL
CHEMBL14249
DrugBank
DB00171
ZINC
ZINC000004261765
PDB chain
1c0g Chain A Residue 376 [
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Receptor-Ligand Complex Structure
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PDB
1c0g
Structural basis for the higher Ca(2+)-activation of the regulated actin-activated myosin ATPase observed with Dictyostelium/Tetrahymena actin chimeras.
Resolution
2.0 Å
Binding residue
(original residue number in PDB)
G13 S14 G15 K18 G156 D157 G158 V159 G182 R210 K213 E214 G302 M305 F306
Binding residue
(residue number reindexed from 1)
G13 S14 G15 K18 G149 D150 G151 V152 G175 R203 K206 E207 G295 M298 F299
Annotation score
5
Enzymatic activity
Enzyme Commision number
3.6.4.-
Gene Ontology
Molecular Function
GO:0005200
structural constituent of cytoskeleton
GO:0005515
protein binding
GO:0005524
ATP binding
GO:0016787
hydrolase activity
GO:0017022
myosin binding
Biological Process
GO:0000281
mitotic cytokinesis
GO:0000902
cell morphogenesis
GO:0001778
plasma membrane repair
GO:0006897
endocytosis
GO:0006909
phagocytosis
GO:0006935
chemotaxis
GO:0006972
hyperosmotic response
GO:0007010
cytoskeleton organization
GO:0016192
vesicle-mediated transport
GO:0042331
phototaxis
GO:0051591
response to cAMP
Cellular Component
GO:0001891
phagocytic cup
GO:0005737
cytoplasm
GO:0005811
lipid droplet
GO:0005856
cytoskeleton
GO:0005884
actin filament
GO:0005911
cell-cell junction
GO:0005938
cell cortex
GO:0015629
actin cytoskeleton
GO:0030027
lamellipodium
GO:0030139
endocytic vesicle
GO:0030864
cortical actin cytoskeleton
GO:0031143
pseudopodium
GO:0031252
cell leading edge
GO:0032009
early phagosome
GO:0032010
phagolysosome
GO:0045335
phagocytic vesicle
GO:0060187
cell pole
GO:0061836
intranuclear rod
GO:0061851
leading edge of lamellipodium
GO:0070685
macropinocytic cup
View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1c0g
,
PDBe:1c0g
,
PDBj:1c0g
PDBsum
1c0g
PubMed
10669610
UniProt
P07830
|ACT1_DICDI Major actin (Gene Name=act1)
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