Structure of PDB 1bzh Chain A Binding Site BS01

Receptor Information
>1bzh Chain A (length=297) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSP
FDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWE
QKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKS
YYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRES
GSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLL
DMRKFRMGLIQTAEQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1bzh Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		R45 Y46 R47 D48 C215 S216 A217 I219 G220 R221 Q262
Binding residue
(residue number reindexed from 1)		R44 Y45 R46 D47 C214 S215 A216 I218 G219 R220 Q261
Enzymatic activity
Catalytic site (original residue number in PDB) D181 C215 R221 S222 Q262
Catalytic site (residue number reindexed from 1) D180 C214 R220 S221 Q261
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1bzh, PDBe:1bzh, PDBj:1bzh
PDBsum1bzh
PubMed9922143
UniProtP18031|PTN1_HUMAN Tyrosine-protein phosphatase non-receptor type 1 (Gene Name=PTPN1)

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