Structure of PDB 1bsj Chain A Binding Site BS01

Receptor Information

>1bsj Chain A (length=166) Species: 562 (Escherichia coli)

SVLQVLHIPDERLRKVAKPVEEVNAEIQRIVDDMFETMYAEEGIGLAATQ
VDIHQRIIVIDVSENRDERLVLINPELLEKSGETGIEEGCLSIPEQRALV
PRAEKVKIRALDRDGKPFELEADGLLAICIQHEMDHLVGKLFMDYLSPLK
QQRIRQKVEKLDRLKA

Ligand information

• Ligand ID: CO
• InChI: InChI=1S/Co/q+2
• InChIKey: XLJKHNWPARRRJB-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Co+2]
  CACTVS 3.341: [Co++]
• Formula: Co
• Name: COBALT (II) ION
• DrugBank: DB14205
• PDB chain: 1bsj Chain A Residue 169

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1bsj Structural basis for the design of antibiotics targeting peptide deformylase.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): Q50 C90 H132 H136
• Binding residue (residue number reindexed from 1): Q50 C90 H132 H136
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): G45 Q50 C90 L91 H132 E133 H136
• Catalytic site (residue number reindexed from 1): G45 Q50 C90 L91 H132 E133 H136
• Enzyme Commision number: 3.5.1.88: peptide deformylase.

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0008198 ferrous iron binding
• GO:0008270 zinc ion binding
• GO:0016787 hydrolase activity
• GO:0042586 peptide deformylase activity
• GO:0043022 ribosome binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006412 translation
• GO:0043686 co-translational protein modification

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:1bsj, PDBe:1bsj, PDBj:1bsj
• PDBsum: 1bsj
• PubMed: 10200158
• UniProt: P0A6K3|DEF_ECOLI Peptide deformylase (Gene Name=def)