Structure of PDB 1bs2 Chain A Binding Site BS01

Receptor Information
>1bs2 Chain A (length=603) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ANMISQLKKLSIAEPAVAKDSHPDVNIVDLMRNYISQELSKISGVDSSLI
FPALEWTNTMERGDLLIPIPRLRIKGANPKDLAVQWAEKFPCGDFLEKVE
ANGPFIQFFFNPQFLAKLVIPDILTRKEDYGSCKLVENKKVIIEFSSPNI
AKPFHAGHLRSTIIGGFLANLYEKLGWEVIRMNYLGDWGKQFGLLAVGFE
RYGNEEALVKDPIHHLFDVYVRINKDIEEEGDSIPLEQSTNGKAREYFKR
MEDGDEEALKIWKRFREFSIEKYIDTYARLNIKYDVYSGESQVSKESMLK
AIDLFKEKGLTHEDKGAVLIDLTKFNKKLGKAIVQKSDGTTLYLTRDVGA
AMDRYEKYHFDKMIYVIASQQDLHAAQFFEILKQMGFEWAKDLQHVNFGM
VQGMSTRKGTVVFLDNILEETKEKMHEVMKKNENKYAQIEHPEEVADLVG
ISAVMIQDMQGKRINNYEFKWERMLSFEGDTGPYLQYAHSRLRSVERNAS
GITQEKWINADFSLLKEPAAKLLIRLLGQYPDVLRNAIKTHEPTTVVTYL
FKLTHQVSSCYDVLWVAGQTEELATARLALYGAARQVLYNGMRLLGLTPV
ERM
Ligand information
Ligand IDARG
InChIInChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1
InChIKeyODKSFYDXXFIFQN-BYPYZUCNSA-O
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(CC(C(=O)O)N)CNC(=[NH2+])N
CACTVS 3.341N[C@@H](CCCNC(N)=[NH2+])C(O)=O
OpenEye OEToolkits 1.5.0C(C[C@@H](C(=O)O)N)CNC(=[NH2+])N
CACTVS 3.341N[CH](CCCNC(N)=[NH2+])C(O)=O
ACDLabs 10.04O=C(O)C(N)CCCN\C(=[NH2+])N
FormulaC6 H15 N4 O2
NameARGININE
ChEMBL
DrugBank
ZINC
PDB chain1bs2 Chain A Residue 900 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1bs2 L-arginine recognition by yeast arginyl-tRNA synthetase.
Resolution2.75 Å
Binding residue
(original residue number in PDB)		E148 N153 H162 Y188 Y347 D351 Y369
Binding residue
(residue number reindexed from 1)		E144 N149 H158 Y184 Y343 D347 Y365
Annotation score5
Enzymatic activity
Catalytic site (original residue number in PDB) K156 H159 H162
Catalytic site (residue number reindexed from 1) K152 H155 H158
Enzyme Commision number 6.1.1.19: arginine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004814 arginine-tRNA ligase activity
GO:0005524 ATP binding
GO:1990825 sequence-specific mRNA binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006420 arginyl-tRNA aminoacylation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1bs2, PDBe:1bs2, PDBj:1bs2
PDBsum1bs2
PubMed9736621
UniProtQ05506|SYRC_YEAST Arginine--tRNA ligase, cytoplasmic (Gene Name=YDR341C)

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