Structure of PDB 1bg1 Chain A Binding Site BS01

Receptor Information
>1bg1 Chain A (length=559) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDS
VTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWK
RRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYK
GDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQ
FTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVM
NMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETE
VYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFT
KPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQI
TWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERE
RAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGSTQIQSVEPYTKQQ
LNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRAAPYLK
TKFICVTPF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1bg1 Three-dimensional structure of the Stat3beta homodimer bound to DNA.
Resolution2.25 Å
Binding residue
(original residue number in PDB)		R382 R417 I431 V432 S465 N466 Q469
Binding residue
(residue number reindexed from 1)		R238 R273 I287 V288 S321 N322 Q325
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0007165 signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1bg1, PDBe:1bg1, PDBj:1bg1
PDBsum1bg1
PubMed9671298
UniProtP42227|STAT3_MOUSE Signal transducer and activator of transcription 3 (Gene Name=Stat3)

[Back to BioLiP]